Benefit to patients and the NHS of cardiac magnetic resonance imaging (CMR) after Primary percutaneous coronary Intervention (PPCI) Pathway Activation

Sponsor: University of Bristol 

REC Number: 12/SW/0326

Status: Analysis

Cardiac magnetic resonance imaging (CMR) can be used to provide detailed pictures of the heart and is used by cardiologists to assess heart function and guide treatment in people who had, or were suspected of having, a heart attack.  We want to set up a multicentre registry by making use of data collected by NHS hospitals in the course of providing usual care for those patients.  Such a registry will provide information on CMR use and how CMR influences patient management. 

The PIPA study is determining whether it is feasible to set up such a registry, for example, whether hospitals can retrieve the data we need and whether we can merge data from different sources (for example, data from the Emergency Department and ward, data describing blood and imaging test results) for a particular patient.  We have finished recruiting patients with suspected heart attacks from four hospitals in the UK (Bristol, Leeds Cardiff and Swansea), two with and two without CMR readily available.  We are assembling a database containing information on patient characteristics, details of interventions and clinical outcomes, and whether CMR has been used or not.  We are requesting hospital activity data from NHS Digital on all patients who participated in the study so that we can add information about future hospital care to the database. We are also requesting data from the Office of National Statistics (ONS) where all births and deaths are recorded. Please contact the study teamif you do not wish us to include information about you from NHS Digital or ONS on the database. 

We will provide regular updates about how the study is progressing and the final conclusion about whether or not the registry is feasible and will be extended to all UK centres that deal with emergency or suspected heart attacks.



Contact Information

Chief Investigator: Prof Barney Reeves

Study coordinator: Dr Rachel Brierley


Progenitor cell response after Myocardial Infarction Study

Sponsor: University Hospitals Bristol

REC Number: 09/H0104/58

After a heart attack, stem cells produced in bone marrow are released in large amounts into the blood and travel to the heart to promote the growth of new blood vessels and repair the damage caused by the heart attack.  In people with diabetes this process may be impaired, resulting in less efficient repair and poorer clinical outcomes after a heart attack.

The Promis study is studying patients with and without diabetes who have had a heart attack.  We are collecting blood samples after the heart attack to determine how many stem cells are released in the blood and how these stem cells behave.

Patients also have cardiac magnetic resonance imaging (CMR) scans to investigate the extent of damage to the heart after the heart attack.  We will determine whether the number of stem cells released from bone marrow is influenced by the degree of damage to the heart, and whether the relationship between the number of stem cells released and the amount of damage is lost in patients with diabetes.  


Contact Information

Chief Investigator: Dr Andreas Baumbach

Study coordinator: Lucy Culliford